Studies in Stereochemistry. XVIII

Genetic Studies of Collagen Types Xv and Xviii

Overlapping genomic clones coding for the α1 chain of mouse type XV collagen (Col15a1) were isolated. The gene was found to be 110 kb in length and to contain 40 exons. Analysis of the proximal 5'-flanking region showed properties characteristic of a housekeeping gene promoter, and functional analysis identified cis-acting elements for both positive and negative regulation of Col15a1 gene expre...

Chemistry of bleomycin. XVIII. carbon-13 NMR studies.

During chemical studies of bleomycin, many fragments and derivatives have been isolated and characterized. The 13C-NMR spectra of these compounds were taken and analyzed for structural information, and the complete assignment of the spectra was achieved. The 13C-chemical shift map thus obtained contains information about the structure and conformation and will be useful for studies on the chemi...

ترجمه بخشی از کتاب "critical readings in translation studies"

چکیده در دنیای پیچیده ی امروز، تغییرات زیادی در زندگی بشری در حال وقوع اند و شاهد رقابت های بسیار فشرده ی جوامع در دستیابی به فناوری برتر و قدرت بیشترهستیم. به نظر می رسد که فرد وجامعه مجبورند به طریقی در وضعیت خویش دگرگونی ایجاد کنند تا از قافله ی علم، فناوری، و پیشرفت عقب نمانند. رشته مطالعات ترجمه نیز از این قاعده مستثنا نیست. علی رغم وسعت روز افزون پژوهش در این حوزه و میان رشته ای بودن مطال...

Type Xviii and Xv Collagens: Primary Structure of Human Alpha1(xviii) Chain, Phenotypic Studies of Type Xviii Collagen Single Null and Type Xviii and Xv Collagen Double Null Mice

In this thesis study, the primary structure of the human α1(XVIII) polypeptide was elucidated, its tissue distribution was studied, and the phenotypic changes in the mouse eye due to lack of type XVIII collagen in a knock-out mouse model were studied further. In addition, the consequences of simultaneous lack of both type XVIII and XV collagen were studied in a mouse model lacking both of these...

Xviii. Protein Metabolism in Cystinuria